IgA肾病:小组讨论
McConnachie et al, AJKD © National Kidney Foundation
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在AJKD最近发表的核心课程中，Prapa Pattrapornpisut和同事讨论了免疫球蛋白a肾病(IgAN)是最常见的原发性肾小球肾炎［．．．］
Lentine et al
Intramolecular epitope spreading of the anti–phospholipase A2 receptor antibody (anti-PLA2R) versus baseline multidomain recognition. The reactivity of anti-PLA2R antibodies to a ubiquitous epitope in the cysteine-rich (CysR) domain (left) “spreads” to include subdominant epitopes of the first (center, C-type lectin domain [CTLD1]) and seventh and eighth CTLDs (right, CTLD7 and CTLD8) distinct from the CysR epitope. Disease progression is positively correlated with greater urinary protein excretion and patient age and inversely correlated with the likelihood of remission. An alternative hypothesis is that antibodies to multiple domains are present at the time of diagnosis, and progression of disease is correlated with total anti-PLA2R antibody levels. Abbreviation: FNII, fibronectin type II domain. Figure 1 from 
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